RESUMO
Results of development of new biologically active dressings and up-to-date methodology of local treatment of wounds (based on their differential application according to phase and features of wound process) are demonstrated. Data about main properties and specific activity of new biologically active dressings based on natural and synthetic polymers with immobilized drugs are presented. Future trends and efficacy of their appliance in complex treatment of purulent and necrotic wounds are demonstrated.
Assuntos
Curativos Hidrocoloides , Curativos Biológicos , Polímeros/farmacologia , Polímeros/uso terapêutico , Cicatrização/efeitos dos fármacos , Acrilatos/farmacologia , Acrilatos/uso terapêutico , Alginatos/farmacologia , Alginatos/uso terapêutico , Animais , Curativos Hidrocoloides/tendências , Curativos Biológicos/tendências , Compostos Inorgânicos de Carbono/farmacologia , Compostos Inorgânicos de Carbono/uso terapêutico , Colágeno/análogos & derivados , Colágeno/farmacologia , Colágeno/uso terapêutico , Humanos , Álcool de Polivinil/farmacologia , Álcool de Polivinil/uso terapêutico , Ratos , Cicatrização/fisiologiaRESUMO
Electron-microscopy and autoradiography of granulation tissue in wounds showed that bioactive coating with epidermal growth factor activates functional and proliferative processes in vascular cells (endotheliocytes and pericytes) and fibroblasts and increases the number of cell-to-cell contacts on days 2-3 of therapy. Pronounced activation of proliferative processes resulted in early differentiation of fibroblast cells (on days 3-4) and rapid epithelialization of the wound.
